Controlling Lipid Micelle Stability Using Oligonucleotide Headgroups

The Lipid World: from Catalytic and Informational Headgroups to Micelle Replication and Evolution without Nucleic Acids Arren Bar-even, Barak Shenhav, Ran Kafri and Doron Lancet

Enhanced oligonucleotide–nanoparticle conjugate stability using thioctic acid modified oligonucleotides

Metallic nanoparticles of gold functionalized with oligonucleotides conventionally use a terminal thiol modification and have been used in a wide range of applications. Although readily available, the oligonucleotide-nanoparticle conjugates prepared in this way suffer from a lack of stability when exposed to a variety of small molecules or elevated temperatures. If silver is used in place of go...

Controlling dimensions of polymerized micelles: micelle template versus reaction conditions.

The polymerization of elongated micellar structures offers a novel approach to the production of high aspect ratio, water-soluble amphiphilic nanoparticles. Three different surfactants were synthesized consisting of a cationic surfactant of the form (C(X)H(2X+1))trimethylammonium (where X = 14, 16, or 18) and a vinyl-containing counterion, 4-vinylbenzoate. The resulting polymer-surfactant aggre...

rodbar dam slope stability analysis using neural networks

در این تحقیق شبکه عصبی مصنوعی برای پیش بینی مقادیر ضریب اطمینان و فاکتور ایمنی بحرانی سدهای خاکی ناهمگن ضمن در نظر گرفتن تاثیر نیروی اینرسی زلزله ارائه شده است. ورودی های مدل شامل ارتفاع سد و زاویه شیب بالا دست، ضریب زلزله، ارتفاع آب، پارامترهای مقاومتی هسته و پوسته و خروجی های آن شامل ضریب اطمینان می شود. مهمترین پارامتر مورد نظر در تحلیل پایداری شیب، بدست آوردن فاکتور ایمنی است. در این تحقیق ...

Microfluidic assembly of lipid-based oligonucleotide nanoparticles.

BACKGROUND Oligonucleotides (ONs) have shown great promise as therapeutic agents for various diseases. It is necessary to provide a protocol for preparation of ON-loaded lipid nanoparticles (LNPs) in a reproducible manner on a laboratory scale. MATERIALS AND METHODS A 3-inlet microfluidic (MF) chip-based device was used to synthesize LNPs at the lipid/ON ratio of 10/1 (w/w) and at flow rates ...